Research
The working groups of the institute deal with the function and biogenesis of mitochondria and lysosomes as well as with selenoproteins. The broad scientific spectrum of the projects of the different research groups ranges from basic research to the understanding of pathomechanisms of diseases. Various state-of-the-art techniques are used to analyze questions in model organisms such as baker's yeast, cell cultures or mouse models. In addition, the Core Facility "Analytical Proteomics" is located at the Institute of Biochemistry and Molecular Biology.
The research is funded by the German Research Foundation, the Collaborative Research Center SFB1218 "Mitochondrial regulation of cellular function", the research group FOR2625 "Mechanisms of lysosomal homeostasis" and by industrial cooperations. In addition, there is an endowed professorship on molecular drug discovery funded by Engelhard Arzneimittel.
AG Becker
Our research group investigates the molecular mechanisms of protein biogenesis in mitochondria.
AG Schweizer
Our research group focuses on biochemical mechanisms in rare genetic diseases.
AG Voos
The research group investigates the molecular mechanisms that enable a quality control of mitochondria under normal or stress conditions.
AG Eckhardt
Our research involves analyses of the molecular pathogenesis of various rare genetic diseases and investigates the physiological functions of short peptides.
AG den Brave
One focus of our research is analyses of the molecular pathogenesis of various, rare genetic diseases.
AG Matzner
We are working on a therapy for MLD. The N-glycans of ASA carry mannose 6-phosphate (M6P) residues, via which the enzyme is bound by M6P receptors on the plasma membrane and transported to the lysosome.
AG Winter
Our Philosophy: Cutting Edge Proteomics and Molecular Biology – an Ideal Partnership for a Better Understanding of the Lysosome.