Institute of Biochemistry and Molecular Biology
The Institute of Biochemistry and Molecular Biology is located in a renovated building of the University of Bonn. It combines the charm of a historical building with state-of-the-art laboratory equipment. The working groups of the institute deal with the function and biogenesis of mitochondria and lysosomes as well as with selenoproteins. The broad scientific spectrum of the projects by the various research groups ranges from basic research to understanding the pathomechanisms of diseases. Various state-of-the-art techniques are used to analyze questions in different model organisms such as baker's yeast, cell cultures or mouse models. In addition, the Core Facility "Analytical Proteomics" is located at the Institute of Biochemistry and Molecular Biology. The research is funded by the German Research Foundation, the Collaborative Research Center SFB1218 "Mitochondrial regulation of cellular function", the Priority Program SPP2453 “Integration of mitochondria into the cellular proteostasis network” and by industrial cooperation’s. In addition, there is an endowed professorship on molecular drug discovery funded by Engelhard Arzneimittel.
The Institute of Biochemistry and Molecular Biology conducts teaching in biochemistry and biology for students of human medicine and dentistry. Furthermore, courses are offered in the master's programs "Neuroscience" and "Molecular Cell Biology" as well as for the SciMed program.
Working groups
AG Becker
Our research group investigates the molecular mechanisms of protein biogenesis in mitochondria.
AG Schweizer
Our research group focuses on biochemical mechanisms in rare genetic diseases.
AG Voos
The research group investigates the molecular mechanisms that enable a quality control of mitochondria under normal or stress conditions.
AG Eckhardt
Our research involves analyses of the molecular pathogenesis of various rare genetic diseases and investigates the physiological functions of short peptides.
AG den Brave
One focus of our research is analyses of the molecular pathogenesis of various, rare genetic diseases.
AG Matzner
We are working on a therapy for MLD. The N-glycans of ASA carry mannose 6-phosphate (M6P) residues, via which the enzyme is bound by M6P receptors on the plasma membrane and transported to the lysosome.
AG Winter
Our Philosophy: Cutting Edge Proteomics and Molecular Biology – an Ideal Partnership for a Better Understanding of the Lysosome.
Study provides insight into the organization of proteins in mitochondria
Researchers at the University Hospital Bonn discover a new important function of the folding helper Hsp70
Mitochondria are known to provide energy for our cells, but they also play an important role in the defense against pathogens.
Core Facilities
Core Facility Analytical Proteomics
The Core Facility Analytical Proteomics offers services for a broad range of protein analyses:
- Identification and characterization of proteins
- Detection of posttranslational modifications
- Comparative quantitative analyses of complex proteomes.