Publications
AG Becker
© Uni Bonn

Selected Publications

  • Schulte, U.; den Brave, F., Haupt, A., Gupta, A., Song, J., Müller, C.S., Engelke, J., Mishra, S., Mårtensson, C., Ellenrieder, L., Priesnitz, C., Straub, S.P., Doan, K.N., Kulawiak, B., Bildl, W., Rampelt, H., Wiedemann, N., Pfanner, N., Fakler, B. and Becker, T. Mitochondrial complexome reveals quality control pathways of protein import (2023). Nature 614, 153-159
  • Song, J., Steidle, L., Steymans, I., Singh, J., Sanner, A., Böttinger, L., Winter, D. and Becker, T. (2023). The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase. Nat. Commun. 14, 39
  • Priesnitz, C., Böttinger, L., Zufall, N., Gebert, M., Guiard, B., van der Laan, M. and Becker, T. (2022). Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation. Cell Rep. 39, 1108619
  • Mårtensson, C.U., Priesnitz, C., Song, J., Ellenrieder, L., Doan, K.N., Boos, F., Floerchinger, A., Zufall, N., Oeljeklaus, S., Warscheid, B. and Becker, T. (2019). Mitochondrial protein translocation-associated degradation. Nature 569, 679-683
  • Ellenrieder, L., Dieterle, M.P., Doan, K.N., Mårtensson, C.U., Floerchinger, A., Campo, M.L., Pfanner, N. and Becker, T. (2019). Dual role of mitochondrial porin in metabolite transport across the outer membrane and protein transfer to inner membrane. Mol. Cell 73, 1056-1065
  • Ellenrieder, L., Opaliński, Ł., Becker, L., Krüger, V., Mirus, O., Straub, S.P., Ebell, K., Flinner, N., Stiller, S.B., Guiard, B., Meisinger, C., Wiedemann, N., Schleiff, E., Wagner, R., Pfanner, N. and Becker, T. (2016). Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10. Nat. Commun. 7, 13021
  • Qiu, J., Wenz, L.S., Zerbes, R.M., Oeljeklaus, S., Bohnert, M., Stroud, D.A., Wirth, C., Ellenrieder, L., Thornton, N., Kutik, S., Wiese, S., Schulze-Specking, A., Zufall, N., Chacinska, A., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., Wiedemann, N. and Becker, T. (2013). Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell 154, 596-608

2024

  • Busto, J.V., Ganesan, I., Mathar, H., Steiert, C., Schneider, E.F., Straub, S.P., Ellenrieder, L., Song, J., Stiller, S.B., Lübbert, P., Chatterjee, R., Elsaesser J., Melchionda L., Schug, C., den Brave, F., Schulte, U., Klecker, T., Kraft, C., Fakler, B., Becker, T. and Wiedemann, N. (2024) Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery. Cell Rep. 43, 113805.
  • Horten, P., Song, K., Garlich, J., Hardt, R., Colina-Tenorio, L., Horvath, S.E., Schulte, U., Fakler, F., van der Laan, M., Becker, T., Stuart, R.A., Pfanner, N. and Rampelt, H. (2024) Identification of MIMAS, a multifunctional mega-assembly integrating metabolic and respiratory biogenesis factors of mitochondria. Cell Rep. 43, 113772.
  • den Brave, F., Pfanner, N. and Becker T. (2024) Mitochondrial entry gate as regulatory hub. Biochim. Biophys. Acta 1871, 119529.
  • den Brave, F., Schulte, U., Fakler, B., Pfanner, N. and Becker, T. (2024) Mitochondrial complexome and import network. Trends Cell Biol. doi:10.1016/j.tcb.2023.10.004
  • Bhowmik, R., den Brave, F. and Becker, T. (2024) Modular assembly of mitochondrial b-barrel proteins. Chapter in transmembrane-barrel proteins: methods and protocols: Methods Mol. Biol. 2778, 201-220.
  • Borgert, L., Becker, T. and den Brave, F. (2024) Conserved quality control mechanisms of mitochondrial protein import. J. Inherit. Metab. Dis. 47, 903-916.
  • Steymans, I., and Becker, T. (2024) Monitoring α-helical membrane protein insertion into the outer membrane of yeast cells. Methods Enzym. 707, 39-62.

2023

  • Schulte, U., den Brave, F., Haupt, A., Gupta, A., Song, J., Müller, C.S., Engelke, J., Mishra, S., Mårtensson, C., Ellenrieder, L., Priesnitz, C., Straub, S.P., Doan, K.N., Kulawiak, B., Bildl, W., Rampelt, H., Wiedemann, N., Pfanner, N., Fakler, B. and Becker, T. Mitochondrial complexome reveals quality control pathways of protein import (2023). Nature 614, 153-159.
  • Schulte, U. and Becker, T. A census of complexes by mitochondrial proteins. (2023). Nature doi.org/10.1038/d41586-023-0095-0 (Summary of Schulte et al., 2023, Nature 614, 153-159).  
  • Song, J., Steidle, L., Steymans, I., Singh, J., Sanner, A., Böttinger, L., Winter, D. and Becker, T. (2023). The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase. Nat. Commun. 14, 39.
  • Guhathakurta, S., Erdogdu, N.U., Hoffmann, J.J., Grzadzielewska, I., Schendzielorz, A., Seyfferth, J., Mårtensson, C.U., Corrado, M., Karoutas, A., Warscheid, B., Pfanner, N., Becker, T. and Akhtar, A. (2023) COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nat. Metab.  5, 1931-1952. 
  • Mishra, S., den Brave, F. and Becker, T. (2023). TCA cycle deficiency in multiple sclerosis. Nat. Metab. 5, 1258-1259.
  • Coyne, L.P., Wang, X., Song, J., de Jong, E., Schneider, K., Massa, P.T., Middleton, F.A., Becker, T. and Chen, X.J. (2023) Mitochondrial protein import clogging as a mechanism of disease. eLife 12, e84330.
  • Peker, E., Weiss, K., Song, J., Zarges, C., Gerlich, S., Boehm, V., Trifunovic, A., Langer, T., Gehring, N., Becker, T. and Riemer, J. (2023) A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. J. Cell Biol. 222, e202210019.
  • Takeda, H., Busto, J.V., Lindau, C., Tsutsumi, A., Tomii, K., Imai, K., Yamamori, Y., Hirokawa, T., Motono, C., Ganesan, I., Wenz, L.S., Becker, T., Kikkawa, M., Pfanner, N., Wiedemann, N. and Endo, T. (2023) A multipoint guidance mechanism for b-barrel folding on the SAM complex. Nat. Struct. Mol. Biol. 30, 176-187
  • Rödl, S., den Brave, F., Räschle, M., Kizmaz, B., Lenhard, S., Groh, C., Becker, H., Zimmermann, J., Morgan, B., Richling, E., Becker, T. and Herrmann, J.M. (2023) The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import. Life Sci. Alliance 6, e202201526.

2022

  • Priesnitz, C., Böttinger, L., Zufall, N., Gebert, M., Guiard, B., van der Laan, M. and Becker, T. (2022) Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation. Cell Rep. 39, 1108619
  • Song, J. and Becker T. (2022) Fidelity of organellar protein targeting. Curr. Opin. Cell Biol. 75:102071
  • Li, X., Straub, J., Medeiros, T.C., Mehra, C., den Brave, F., Peker, E., Atanassov, I., Stillger, K., Michaelis, J.B., Burbridge, E., Adrain, C., Münch, C., Riemer, J., Becker, T. and Pernas, L.F. (2022) Mitochondria shed their outer membrane in response to infection-induced stress. Science 375, eabi4343
  • Hoffmann, J.J. and Becker, T. (2022) Crosstalk between mitochondrial protein import and lipids. Int. J. Mol. Sci. 23, 5275
  • Rampelt, H., Wollweber, F., Licheva, M., de Boer, R., Perschil, I., Steidle, L., Becker T., Bohnert, M., van der Klei, I., Kraft, C., van der Laan, M. and Pfanner, N. (2022) Dual Role of Mic10 in mitochondrial cristae organization and ATP synthase-linked metabolic adaptation and respiratory growth. Cell Rep. 38, 110290

2021

  • Winter, D. and Becker, T. (2021) Surveying the mitochondrial proteome. Nature Cell Biology 23, 1216-1217
  • den Brave, F., Gupta, A. and Becker, T. (2021) Protein quality control at the mitochondrial surface. Front. Cell Dev. 9, 795685
  • den Brave, F., Engelke, J. and Becker, T. (2021) Quality control of protein import into mitochondria. Biochem. J. 478, 3125-3143
  • Takeda, H., Tsutsumi, A., Nishizawa, T., Lindau C., Busto, J.V., Wenz, L.S., Ellenrieder, L., Imai, K., Straub, S.P., Mossmann, W., Qiu, J., Yamamori, Y., Tomii, K., Suzuki, J., Murata, T., Ogasawara, S., Nureki, O., Becker, T., Pfanner, N., Wiedemann, N., Kikkawa, M. and Endo, T. (2021) Mitochondrial sorting and assembly machinery operates by β-barrel switching. Nature 590, 163-169
  • Kelly, B., Carrizo, G.E., Edwards-Hicks, J., Sanin, D.E., Stanczak, M.A., Priesnitz, C., Flachsmann, L.J., Curtis, J.D., Mittler, G., Musa, Y., Becker, T., Buescher, J.M. and Pearce, E.L. (2021) Sulfur sequestration promotes multicellularity during nutrient limitation. Nature 591, 471-476
  • Song, J., Herrmann, J.M. and Becker, T. (2021) Quality control of the mitochondrial proteome. Nat. Rev. Mol. Cell Biol. 22, 54-70
  • Gupta, A. and Becker, T. (2021) Mechanisms and pathways of mitochondrial outer membrane protein biogenesis. Biochim. Biophys. Acta 1862, 148323

2020

  • den Brave, F. and Becker, T. (2020) Supercomplex formation boosts respiration. EMBO Rep. e51830
  • Doan, N.K., Grevel, A., Mårtensson, C.U., Ellenrieder, L., Thornton, N., Wenz, L.S., Opalinski, L., Guiard, B., Pfanner, N. and Becker, T. (2020) The mitochondrial import complex MIM functions as main translocase for α-helical outer membrane proteins. Cell Rep. 31, 107567
  • Li, Y., Lou, W., Grevel, A., Böttinger, L., Liang, Z., Ji, J., Patil, V.A., Liu, J., Ye, C., Hüttemann, M., Becker, T. and Greenberg, M.L. (2020) Cardiolipin-deficient cells have decreased levels of the iron-sulfur biogenesis protein frataxin. J. Biol. Chem. 295, 11928-11937
  • Priesnitz, C., Pfanner, N., and Becker, T. (2020) Studying protein import into mitochondria. Methods Cell Biol.155, 45-79
  • Grevel, A., and Becker, T. (2020). Porins as helpers in mitochondrial protein translocation. Biol. Chem. 401, 699-708

2019

  • Mårtensson, C.U., Priesnitz, C., Song, J., Ellenrieder, L., Doan, K.N., Boos, F., Floerchinger, A., Zufall, N., Oeljeklaus, S., Warscheid, B. and Becker, T. (2019) Mitochondrial protein translocation-associated degradation. Nature 569, 679-683
  • Ellenrieder, L., Dieterle, M.P., Doan, K.N., Mårtensson, C.U., Floerchinger, A., Campo, M.L., Pfanner, N. and Becker, T. (2019) Dual role of mitochondrial porin in metabolite transport across the outer membrane and protein transfer to inner membrane. Mol. Cell 73, 1056-1065
  • Araiso, Y., Tsutsumi, A., Qiu, J., Imai, K., Shiota, T., Song, J., Lindau, C., Wenz, L.S., Sakaue, H., Yunoki, K., Kawano, S., Suzuki, J., Wischnewski, M., Schütze, C., Ariyama, H., Ando, T., Becker, T., Lithgow, T., Pfanner, N., Kikkawa, M., and Endo, T. (2019) Structure of mitochondrial import gate reveals distinct preprotein paths. Nature. 575, 395-401
  • Becker, T., Song, J, and Pfanner, N. (2019) Versatility of preprotein transfer from the cytosol to mitochondria. Trends Cell Biol. 29, 679-683
  • Song, J., and Becker, T. (2019) Clogging the mitochondrial protein-entry gate promotes obesity. Nature Metab. 1, 1175-1176
  • Doan, K.N., Ellenrieder, L. and Becker, T. (2019) Mitochondrial protein links protein biogenesis to metabolism. Curr. Genet. 65, 899-903
  • Grevel, A., Pfanner, N., and Becker, T. (2019) Coupling of import and assembly pathways in mitochondrial protein biogenesis. Biol. Chem. 401,117-129.

2018

  • Opaliński, Ł., Song, J., Priesnitz, C., Wenz, L.S., Oeljeklaus, S., Warscheid, B., Pfanner, N. and Becker, T. (2018) Recruitment of cytosolic J-proteins by TOM receptors promotes mitochondrial protein biogenesis. Cell Rep. 25, 2036-2043
  • Priesnitz, C. and Becker, T. (2018) Pathways to balance mitochondrial translation and protein import. Genes Dev. 32, 1285-1296
  • Böttinger, L., Mårtensson, C.U., Song, J., Zufall, N., Wiedemann, N. and Becker, T. (2018) Respiratory chain supercomplexes associate with the cysteine desulfurase complex of the iron-sulfur cluster assembly machinery. Mol. Biol. Cell 29, 776-785
  • Höhr, A.I.C., Lindau, C., Wirth, C., Qiu J., Stroud, D.A., Kutik, S., Guiard, B., Hunte, C., Becker, T., Pfanner, N. and Wiedemann, N. (2018) Membrane protein insertion through a mitochondrial β-barrel gate. Science 359, eaah6834
  • González Montoro, A., Auffarth, K., Hönscher, C., Bohnert, M., Becker, T., Warscheid, B., Reggiori, F., van der Laan, M., Fröhlich, F. and Ungermann, C. (2018) Vps39 interacts with Tom40 to establish one of two functionally distinct vacuole-mitochondria contact sites. Dev. Cell 45, 621-636
  • Becker, T. and Wagner, R. (2018) Mitochondrial outer membrane channels: emerging diversity in transport processes. BioEssays 1800013
  • Song, J., Pfanner, N. and Becker, T. (2018) Assembling the mitochondrial ATP synthase. Proc. Natl. Acad. Sci. USA 20, 2850-2852
  • Wagner, A., Di Bartolomeo, F., Klein, I., Hrastnik, C., Doan, K.N., Becker, T. and Daum, G. (2018) Identification and characterization of the mitochondrial membrane sorting signals in phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae. Biochim. Biophys. Acta 1863, 117-125

2017

  •  Krüger, V.*, Becker, T.*, Becker, L., Montilla-Martinez, M., Ellenrieder, L., Vögtle, F.N., Meyer, H., Ryan, M., Wiedemann, N., Warscheid, B., Pfanner, N., Wagner, R. and Meisinger, C. (2017) Identification of new channels by systematic analysis of the mitochondrial outer membrane. J. Cell Biol. 216, 3485-3495 (*equal contribution)
  • Mårtensson, C.U. and Becker, T. (2017) Acylglycerol Kinase: Mitochondrial protein transport meets lipid biosynthesis. Trends Cell Biol. 27, 700-702
  • Di Bartolomeo, F., Doan, K.N., Athenstaedt, K.#, Becker, T.# and Daum, G.# (2017) Involvement of a putative substrate binding site in the biogenesis and assembly of phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae. Biochim Biophys Acta. 1862, 716-725 (#corresponding author)
  • Ellenrieder, L., Rampelt, H. and Becker, T. (2017) Connection of protein transport and organelle contact sites in mitochondria. J. Mol. Biol. 429, 2148-2160
  • Mårtensson, C.U., Doan, K.N. and Becker, T. (2017) Effects of lipids on mitochondrial functions. Biochim Biophys Acta. 182, 102-113

2016

  • Ellenrieder, L., Opalinski, L., Becker, L., Krüger, V., Mirus, O., Straub, S.P., Ebell, K., Flinner, N., Stiller, S.B., Guiard, B., Meisinger, C., Wiedemann, N., Schleiff, E., Wagner, R., Pfanner, N., and Becker, T. (2016) Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10. Nat. Commun. 7:13021
  • Chatterjee, A., Seyfferth, J., Lucci, J., Gilsbach, R., Preissl, S., Böttinger, L., Mårtensson, C.U., Panhale, A., Stehle, T., Kretz, O., Sahyoun, A.H., Avilov, S., Eimer, S., Hein, L., Pfanner, N., Becker, T. and Akhtar, A. (2016) MOF acetyl transferase regulates transcription and respiration in mitochondria. Cell 167, 722-738
  • Schuler, M.H., Di Bartolomeo, F., Mårtensson, C.U., Daum, G. and Becker, T. (2016) Phosphatidylcholine affects inner membrane protein translocases of mitochondria. J. Biol. Chem. 291, 18718-18729
  • Bionda, T., Gross, L., Becker, T., Papasotiriou, D.G., Leisegang, M.S., Karas, M. and Schleiff, E. (2016) Eukaryotic Hsp70 chaperones in the intermembrane space of chloroplasts. Planta 243, 733-747
  • Müller, C.S., Bildl, W., Haupt, A., Ellenrieder, L., Becker, T., Hunte, C., Fakler, B. and Schulte, U. (2016) Cryo-slicing BN-MS – a novel technology for high-resolution complexome profiling. Mol. Cell. Proteomics 15, 669-681
  • Böttinger, L., Ellenrieder, L. and Becker, T. (2016) How lipids modulate mitochondrial protein import. J. Bioenerg. Biomembr. 48, 125-135

2015

  • Wenz, L.S., Ellenrieder, L., Qiu, J., Bohnert, M., Zufall, N., van der Laan, M., Pfanner, N., Wiedemann, N. and Becker, T. (2015) Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis. J. Cell. Biol. 210, 1047-1054
  • Schuler, M.H., Di Bartolomeo, F., Böttinger, L., Horvath, S.E., Wenz, L.S., Daum, G. and Becker, T. (2015) Phosphatidylcholine affects the role of the sorting and assembly machinery in the biogenesis of mitochondrial β-barrel proteins. J. Biol. Chem. 290, 26523-26532
  • Böttinger, L., Oeljeklaus, S., Guiard, B., Rospert, S., Warscheid, B. and Becker, T. (2015) The mitochondrial heat shock protein 70 (Hsp70) and Hsp10 cooperate in the formation of Hsp60 complexes. J. Biol. Chem. 290, 11611-11622
  • Ellenrieder, L., Martensson, C.U. and Becker, T. (2015) Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Biol. Chem. 396, 1199-1213
  • Wenz, L.S., Opalinski, L., Wiedemann, N. and Becker, T. (2015) Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta. 1853, 1119-1129
  • Höhr, A.I.C., Straub, S.P., Warscheid, B., Becker, T. and Wiedemann, N. (2015) Assembly of β-barrel protein in the mitochondrial outer membrane. Biochim Biophys Acta. 1853, 74-88

2014

  • Ieva, R., Schrempp, S.G., Opalinski, L., Wollweber, F., Höß, P., Heißwolf, A., Gebert, M., Zhang, Y., Guiard, B., Rospert, S., Becker, T., Chacinska, A., Pfanner, N. and van der Laan, M. (2014) Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Mol. Cell 56, 641-652
  • Wenz, L.S., Opalinski, L., Schuler, M.H., Ellenrieder, L., Ieva, R., Böttinger, L., Qiu, J., van der Laan, M., Wiedemann, N., Guiard, B., Pfanner, N. and Becker, T. (2014) The presequence pathway is involved in protein sorting to the mitochondrial outer membrane. EMBO Rep. 15, 678-685
  • Opalinski, L., Becker, T. and Pfanner, N. (2014) Clearing tail-anchored proteins from mitochondria. Proc. Natl. Acad. Sci. USA 111, 7888-7889
  • Wenz, L.S., Qiu, J., Becker, T. and Wiedemann, N. (2014) Biogenesis and folding of β-barrel membrane proteins. Cell Cycle 13, 169-170

2013

  • Böttinger, L., Guiard, B., Oeljeklaus, S., Kulawiak, B., Zufall, N., Wiedemann, N., Warscheid, B., van der Laan, M. and Becker, T. (2013) A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase. Mol. Biol. Cell. 24, 2609-2619
  • Qiu, J., Wenz, L.S., Zerbes, R.M., Oeljeklaus, S., Bohnert, M., Stroud, D.A., Wirth, C., Ellenrieder, L., Thornton, N., Kutik, S., Wiese, S., Schulze-Specking, A., Zufall, N., Chacinska, A., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., Wiedemann, N. and Becker, T. (2013) Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell 154, 596-608
  • Becker, T.*, Horvath, S.E.*, Böttinger, L.*, Gebert, N., Daum, G. and Pfanner, N. (2013) Role of phosphatidylethanolamine in the biogenesis of mitochondrial outer membrane proteins. J. Biol. Chem. 288, 16451-16459. (*equal contribution)
  • Flinner, N., Ellenrieder, L., Stiller, S.B., Becker, T., Schleiff, E. and Mirus, O. (2013) Mdm10 is an ancient eukaryotic porin co-occuring with the ERMES complex. Biochim. Biophys. Acta. 1833, 3314-3325

2012

  • Horvath, S.E., Böttinger, L., Vögtle, F.N., Wiedemann, N., Meisinger, C., Becker, T.# and Daum, G.# (2012) Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1. J. Biol. Chem. 287, 36744-36755 (#co-corresponding)
  • Böttinger, L., Horvath, S.E., Kleinschroth, T., Hunte, C., Daum, G., Pfanner, N. and Becker, T. (2012) Phosphatidylethanolamine and cardiolipin differently affect the stability of mitochondrial respiratory chain supercomplexes. J. Mol. Biol. 423, 677-686
  • Bohnert, M., Wenz, L.S., Zerbes, R.M., Horvath, S.E., Stroud, D.A., von der Malsburg, K., Müller, J.M., Oeljeklaus, S., Perschill, I., Warscheid, B., Chacinska, A., Veenhuis, M., van der Klei, I.J., Daum, G., Wiedemann, N., Becker, T., Pfanner, N. and van der Laan, M. (2012) Role of MINOS in protein biogenesis of the mitochondrial outer membrane. Mol. Biol. Cell 23, 3948-3956
  • Zerbes, R.M., Bohnert, M., Stroud, D.A., von der Malsburg, K., Kram, A., Oeljeklaus, S., Warscheid, B., Becker, T., Wiedemann, N., Veenhuis, M., van der Klei, I.J., Pfanner, N. and van der Laan, M. (2012) Role of MINOS in mitochondrial membrane architecture: Cristae morphology and outer membrane interactions differentially depend on mitofilin domains. J. Mol. Biol. 422, 183-191
  • Elkehal, R., Becker, T., Sommer, M.S., Königer, M. and Schleiff, E. (2012) Specific lipids influence the import capacity of the chloroplasts outer envelope precursor protein translocon. Biochim. Biophys. Acta, 1823, 1033-1040
  • Wenz, L.S., Pfanner, N. and Becker, T. (2012) Mitochondriale Systeme für den Import von Proteinen. Biospektrum 18, 706-709
  • Böttinger, L. and Becker, T. (2012) Protein quality control in the intermembrane space of mitochondria. J. Mol. Biol. 424, 225-226
  • Becker, T., Böttinger, L. and Pfanner, N. (2012) Mitochondrial protein import: from transport pathways to an integrated network. Trends Biochem. Sci., 37, 85-91

2011

  • von der Malsburg, K., Müller, J.M., Bohnert, M., Oeljeklaus, S., Kwiatkowska, P., Becker, T., Loniewska-Lwowska, A., Wiese, S., Rao, S., Milenkovic, D., Hutu, D.P., Zerbes, R.M., Schulze-Specking, A., Meyer, H.E., Martinou, J-C., Rospert, S., Rehling, P., Meisinger, C., Veenhuis, M., Warscheid, B., van der Klei, I.J., Pfanner, N., Chacinska, A. and van der Laan, M. (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev. Cell, 21, 694-707
  • Becker, T., Wenz, L.S., Krüger, V., Lehmann, W., Müller, J.M., Goroncy, L., Zufall, N., Lithgow, T., Guiard, B., Chacinska, A., Wagner, R., Meisinger, C. and Pfanner, N. (2011) The mitochondrial import protein Mim1 promotes biogenesis of multi-spanning outer membrane proteins. J. Cell. Biol. 194, 387-395
  • Stroud, D.A., Becker, T., Qiu, J., Stojanovski, D., Pfannschmidt, S., Wirth, C., Hunte, C., Guiard, B., Meisinger, C., Pfanner, N. and Wiedemann, N. (2011) Biogenesis of mitochondrial β-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex. Mol. Biol. Cell. 22, 2823-2833
  • Becker, T., Wenz, L.S., Thornton, N., Stroud, D.A., Meisinger, C., Wiedemann, N. and Pfanner, N. (2011) Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane. J. Mol. Biol. 405, 113-124
  • Schleiff, E., Maier, U.G. and Becker, T. (2011) Omp85 in eukaryotic systems: one protein family with distinct functions. Biol. Chem. 392, 21-27
  • Schleiff, E. and Becker, T. (2011) Common ground for protein translocation: access control for mitochondria and chloroplasts. Nat. Rev. Mol. Cell Biol. 12, 48-59

2010

  • Becker, T., Guiard, B., Thornton, N., Zufall, N., Stroud, D.A., Wiedemann, N. and Pfanner, N. (2010) Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction with the SAM complex. Mol. Biol. Cell 14, 3106-3113
  • Thornton, N., Stroud, D.A., Milenkovic, D., Guiard, B., Pfanner, N. and Becker, T. (2010) Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of α-helical outer membrane proteins. J. Mol. Biol. 396, 540-549
  • Kamenisch, Y., Fousteri, M., Knoch, J., von Thaler, A-K., Fehrenbacher, B., Kato, H., Becker, T., Dolle M., Kuiper, R., Majora, M., Schaller, M., van der Horst, G., van Steeg, H., Röcken, M., Rapaport, D., Krutmann, J., Mullenders, L.H. and Berneburg, M. (2010) Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J. Exp. Med. 207, 379-390

2009

  • Gebert, N., Joshi, A.S., Kutik, S., Becker, T., McKenzie, M., Guan, X.L., Mooga, V.P., Stroud, D.S., Kulharni, G., Wenk, M.R., Rehling, P., Meisinger, C., Ryan, M.T., Wiedemann, N., Greenberg, M.L. and Pfanner, N. (2009) Mitochondrial Cardiolipin involved in outer-membrane protein biogenesis: Implications for the Barth Syndrome. Curr. Biol. 19, 2133-2139
  • Becker, T., Gebert, M., Pfanner, N. and van der Laan, M. (2009) Biogenesis of mitochondrial membrane proteins. Curr. Opin. Cell Biol. 21, 484-493

2008

  • Kutik, S., Stojanovski, D., Becker, L., Becker, T., Meinecke M., Krüger, V., Prinz, C., Meisinger, C., Guiard, B., Wagner, R., Pfanner, N. and Wiedemann, N. (2008) Dissecting membrane insertion of mitochondrial β-barrel proteins. Cell, 132, 1011-1024
  • Kutik, S., Stojanovski, D., Becker, T., Stroud, D.A., Becker, L., Meineke, M., Krüger, V., Prinz, C., Guiard, B., Wagner, R., Meisinger, C., Pfanner, N. and Wiedemann, N. (2008) The mitochondrial β-signal and protein sorting. Cell 135, 1159-1160 (comment to Kutik et al., 2008, Cell 132, 1011-1024)
  • Becker, T., Pfannschmidt, S., Guiard, B., Stojanovski, D., Milenkovic, D., Kutik, S., Pfanner, Meisinger, C. and Wiedemann, N. (2008) Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J. Biol. Chem. 283, 120-127
  • Becker, T., Vögtle, F.N., Stojanovski, D. and Meisinger, C. (2008) Sorting and assembly of mitochondrial outer membrane proteins. Biochim. Biophys. Acta. 1777, 447-563

2007

  • Meisinger, C., Pfannschmidt, S., Rissler, M., Milenkovic, D., Becker, T., Stojanovski, D., Youngman, M.J., Jensen, R.E., Chacinska, A., Giuard, B., Pfanner, N. and Wiedemann, N. (2007) The morphology proteins Mdm12/Mmm1 function in the major β-barrel assembly pathway of mitochondria. EMBO J., 26, 2229-2239
  • Kempa S., Rozhon, W., Samaj, J., Erban, A., Baluska, F., Becker T., Haselmayer, J., Schleiff, E., Kopka, J., Hirt, H. and Jonak, C. (2007) A plastid-localised glycogen synthase kinase 3 modulates stress tolerance and carbohydrate metabolism. Plant J., 47, 1076-1090
  • Qbadou, S., Becker, T., Bionda, T., Reger, K., Ruprecht, M., Soll, J. and Schleiff, E. (2007) Toc64 – A Preprotein-receptor at the outer membrane with bipartide function. J. Mol. Biol., 367, 1330-1346

2006

  • Qbadou, S. *, Becker, T*., Mirus, O., Sohrt, K., Tews, I., Soll, J. and Schleiff, E. (2006) The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64. EMBO J., 25, 1836-1847 (*equal contribution)

2005

  • Hemmler, R., Becker T., Schleiff, E., Bölter, B., Stahl, T., Soll, J., Götze, T.A., Braams, S. and Wagner, R. (2005) Molecular properties of Oep21 an ATP regulated anion selective solute channel from the chloroplasts outer membrane. J. Biol. Chem. 281, 12020-12029
  • Bonardi, V., Pesaresi, P., Becker, T., Schleiff, E., Wagner, R., Pfannschmidt, T., Jahns, P. and Leister, D. (2005) PSII core phosphorylation and photosynthetic acclimation require two different protein kinases in Arabidopsis. Nature, 437, 1179-1182
  • Ertel, F., Mirus, O., Bredemeyer, R., Moslavac, S., Becker, T. and Schleiff, E. (2005) The evolutionary related β-barrel polypeptide transporters from P. sativum and Anabaena contain two distinct functional domains. J. Biol. Chem., 280, 28281-28289
  • Becker T., Qbadou S., Jelic, M. and Schleiff E. (2005) Let´s talk about…chloroplast import. Plant Biol. 7, 1-14
  • Becker T., Soll, J., and Schleiff E. (2005) Chaperone systems in chloroplasts. In Handbook of protein folding. Edited by Kiefhaber, T. and Buchner J., 1019-1064

2004

  • Becker, T.*, Jelic, M.*, Vojta. A., Radunz, A., Soll. J. and Schleiff, E. (2004) Preprotein recognition by the Toc complex. EMBO J., 23, 520-530. (*equal contribution)
  • Vojta, A., Alavi, M., Becker, T., Hörmann, F., Küchler, M., Soll, J., Thomson, R. and Schleiff, E. (2004) The protein translocon of the plastid envelopes. J. Biol. Chem. 279, 21401-21405
  • Becker, T., Hritz, J., Vogel, M., Caliebe, A., Bukau, B., Soll, J. and Schleiff E. (2004) Toc12, a novel subunit of the intermembrane space preprotein translocon of chloroplasts. Mol. Biol. Cell, 15, 5130-5144

2003

  • Schleiff, E., Eichacker, L.A., Eckart, K., Becker, T., Mirus, O., Stahl, T. and Soll, J. (2003) Prediction of the plant β-barrel proteome: a case study of the chloroplast outer envelope. Protein Sci. 12, 748-759

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